Prophylaxis of fungal infections in transplant patients
نویسندگان
چکیده
Edson Abdala, Sı́lvia Figueiredo Costa, Tania Mara Varejão Strabelli, Lı́gia Camera Pierrotti, Marlova Luzzi Caramori, Luis Sérgio Fonseca de Azevedo, Karim Y. Ibrahim, Frederico Luiz Dulley, Glaucia Fernanda Varkulja, Gilberto de Castro Junior, Gisele Madeira Duboc de Almeida, Heloisa Helena de Souza Marques, Maria Aparecida Shikanai-Yasuda, Comissão de Infecção em Imunodeprimidos, Hospital das Clı́nicas da Faculdade de Medicina da USP I Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Liver Transplant Service, São Paulo/SP, Brazil. II Faculdade de Medicina da Universidade de São Paulo (FMUSP), Department of Infectious and Parasitic Diseases, São Paulo/SP, Brazil. III Instituto do Coração do Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (INCOR-HCFMUSP), Heart Transplant Area, São Paulo/SP, Brazil. IV Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Clinical Division of Infectious Diseases, São Paulo/SP, Brazil. V Instituto do Coração do Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (INCORHCFMUSP), Lung Transplant Unit, São Paulo/SP, Brazil. VI Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Kidney Transplant Unit, Urology Division, São Paulo/SP, Brazil. VII Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Disciplina de Hematologia, Serviço de Transplante de Medula Óssea, São Paulo/SP, Brazil. VIII Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (ICHC-HCFMUSP), Infection Control Committee of the Instituto Central, São Paulo/SP, Brazil. IX Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo/SP, Brazil. X Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Division of Central Laboratory, (HCFMUSP), São Paulo/SP, Brazil. XI Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo (ICr-HCFMUSP), Instituto da Criança, São Paulo/SP, Brazil.
منابع مشابه
Antifungal Prophylaxis in Liver Transplant Recipients.
Although the overall incidence of fungal infections in liver transplant recipients has declined, these infections still contribute significantly to the morbidity and mortality of patients with risk factors for infection. Although antifungal prophylaxis has been widely studied and practiced, no consensus exists on which patients should receive prophylaxis, with which agent, and for what duration...
متن کاملOpportunistic Fungal Infections, Part 1: Antifungal Treatment and Prophylaxis
Patients with advanced HIV-1 infection, those who are receiving chemotherapy for malignancy, and transplant recipients (both hematopoietic stem cell transplant [HSCT] and solid organ transplant [SOT]) are among the populations of immunosuppressed patients at risk for fungal infections. The fungal infections acquired by these patients are a consequence of immunological deficits associated with t...
متن کاملVoriconazole for secondary prophylaxis of invasive fungal infections in allogeneic stem cell transplant recipients: results of the VOSIFI study.
BACKGROUND Recurrence of prior invasive fungal infection (relapse rate of 30-50%) limits the success of stem cell transplantation. Secondary prophylaxis could reduce disease burden and improve survival. DESIGN AND METHODS A prospective, open-label, multicenter trial was conducted evaluating voriconazole (4 mg/kg/12 h intravenously or 200 mg/12 h orally) as secondary antifungal prophylaxis in ...
متن کاملVoriconazole is safe and effective as prophylaxis for early and late fungal infections following allogeneic hematopoietic stem cell transplantation.
Seventy-two patients undergoing allogeneic transplantation were treated with voriconazole (VOR) as antifungal prophylaxis starting from day -2 of transplantation and continuing until withdrawal of immunosuppression. Patients were assessed for safety and the incidence of definite, probable, or possible fungal infection throughout transplantation was evaluated. VOR was well tolerated. Only 14% of...
متن کاملRandomized, double-blind trial of anidulafungin versus fluconazole for prophylaxis of invasive fungal infections in high-risk liver transplant recipients.
Invasive fungal infections (IFIs) are a common complication in liver transplant recipients. There are no previous randomized trials of an echinocandin for the prevention of IFIs in solid organ transplant recipients. In a randomized, double-blind trial conducted at University-affiliated transplant centers, 200 high-risk liver transplant recipients (100 patients per group) received either anidula...
متن کاملInvasive fungal infections in low-risk liver transplant recipients: a multi-center prospective observational study.
Prevention of invasive fungal infections (IFIs) in orthotopic liver transplant (OLT) recipients utilizing postoperative systemic antifungal prophylaxis, typically with fluconazole, is justified among those at high risk for IFI. Use of postoperative antifungal prophylaxis for low-risk OLT recipients is widely practiced but not universally accepted nor supported by data. We conducted a prospectiv...
متن کامل